respiratory toxicity of diesel particulate

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The air quality has become a major issue in the environmental policies of industrialized countries.

Indeed, circumstantial evidence from epidemiological studies conducted over the past twenty years, used to establish a probable relationship between certain pollutants, such as airborne particles and mortality or morbidity of respiratory and cardiovascular.

However, it is not always easy to establish a clear causal relationship between a given pollutant and a health effect. Diesel particles have been implicated in rapidly worsening respiratory diseases such as asthma, to the extent that their small size allows them access to the deep lung.

Recent experimental studies have revealed the molecular mechanisms underlying the inflammatory response induced by these particles. These could go through the production of reactive oxygen species that play
a central role currently recognized in many diseases.

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